Genetics and pathophysiology of neonatal diabetes mellitus

Genetics and pathophysiology of neonatal diabetes mellitus

Neonatal diabetes mellitus (NDM) is the term commonly used to describe diabetes with onset before 6 months-of-age. It occurs in approximately one out of every 100,000-300,000 live births. Although this term encompasses diabetes of any etiology, it is recognized that NDM diagnosed before 6 months-of-age is most often monogenic in nature. Clinically, NDM subgroups include transient (TNDM) and per...

genetics of neonatal diabetes mellitus

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Genetics of neonatal diabetes mellitus.

Genetic Susceptibility to Transient and Permanent Neonatal Diabetes Mellitus

Neonatal diabetes mellitus (NDM) is a rare kind of diabetes characterized by hyperglycemia and low levels of insulin. Clinically, it is categorized into two main types: transient NDM (TNDM) and permanent NDM (PNDM). These types are diagnosed based on duration of insulin dependence early in the disease. In TNDM, diabetes begins in the first few weeks of life with remission in a few months. Howev...

Congenital diabetes mellitus and neonatal pseudodiabetes mellitus.

Diabetes mellitus is very rare in infants. Cases in recent years have been reported by Schwartzman, Crusius and Beirne (1947), by Bertoye and Stefani (1954) and by Keidan (1955), who reviewed the hitherto published cases of infantile diabetes. In Keidan's report 79 cases of infantile diabetes are mentioned, the neonatal cases attracting special interest on account of certain clinical characteri...